Lateral line neuromasts of zebrafish are a well-established model for the study of drug protection from cisplatin or aminoglycoside toxicity because their HCs are considered homologous to mammalian HCs and readily accessible to compounds in vivo (47–49). 12, Biotechnology and Genetic Engineering Reviews, Vol. 93, No. Additionally, bioassays on zebrafish are cheaper and faster than on mice and the teratogenic effects, toxic response and LC 50 (lethal concentration) in zebrafish are similar to results achieved in mice (7). The zebrafish model organism is ... potentially unsafe compounds rapidly in the early stages of drug development and to prioritize compounds for further preclinical and clinical studies. 9, 1 October 2016 | Zebrafish, Vol. A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. 1, Free Radical Biology and Medicine, Vol. Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. Expert Opin Drug Discov. Ribeiro LNM, Rodrigues da Silva GH, Couto VM, Castro SR, Breitkreitz MC, Martinez CS, Igartúa DE, Prieto MJ, de Paula E. Front Chem. 2020 Dec;35(1):1765-1772. doi: 10.1080/14756366.2020.1822829. extracts in zebrafish embryos and human umbilical vein endothelial cells, Automated manipulation of zebrafish embryos using an electrothermal microgripper, Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: 10, 2 December 2014 | PLoS ONE, Vol. 9, No. 3, Journal of Developmental Biology, Vol. Please enable it to take advantage of the complete set of features! 37, No. Zebrafish as a genetic model in pre-clinical drug testing and screening Gibert, Y, Trengove, M C and Ward, A C 2013, Zebrafish as a genetic model in pre-clinical drug testing and screening, Current Medicinal Chemistry, vol. 15, No. 6, 2 February 2016 | Marine Biotechnology, Vol. ), Cytoprotective activities of water-soluble fullerenes in zebrafish models, N-Acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro, The Effects of Aromatase Inhibitors and Selective Estrogen Receptor Modulators on Eye Development in the Zebrafish ( Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. Zebrafish. As an initial screen for drug-induced hepatotoxicity, drug effects on zebrafish liver tissue can be assessed visually without the need for complicated surgical procedures. activity, Zebrafish as a Model for Systems Medicine R&D: Rethinking the Metabolic Effects of Carrier Solvents and Culture Buffers Determined by 1H NMR Metabolomics, Application of different enzyme assays and biomarkers for pollution monitoring of the marine environment, Zebrafish: A Versatile Animal Model for Fertility Research, Advancing epilepsy treatment through personalized genetic zebrafish models, Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish, Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio, Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio), Opposing effects of ketamine and acetyl l-carnitine on the serotonergic system of zebrafish, The promise of zebrafish as a chemical screening tool in cancer therapy, Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay, Microcystin-RR exposure results in growth impairment by disrupting thyroid endocrine in zebrafish larvae, Synergistic Potentials of Coffee on Injured Pancreatic Islets and Insulin Action via K Zebrafish is an ideal model for the study of toxicity screening because a zebrafish embryo mimics the complexity of interactions in the human body. Specialized in the efficient development of your preclinical program. 2, 26 April 2011 | Biomedical Optics Express, Vol. 4, 24 May 2016 | Scientific Reports, Vol. 6, 30 March 2013 | Archives of Toxicology, Vol. This is indicated by homologous hair cell physiology, (241,242) similar auditory anatomy, and neuronal signaling (243) and is further supported by apparently conserved genetic regulation. 1, 1 December 2008 | Expert Opinion on Drug Discovery, Vol. 10, No. Danio rerio 4, Neurobiology of Learning and Memory, Vol. 79, No. 160, No. Sci Rep 9 9615 PMID: 31270336 . 83, Future Medicinal Chemistry, Vol. 1, 23 February 2018 | Frontiers in Pharmacology, Vol. 12, 5 October 2018 | BMC Complementary and Alternative Medicine, Vol. 1, No. Caenorhabditis elegans a drug known to protect against vascular leakage in murine models, as a lead hit, thereby validating the utility of our model for sepsis drug screens. Use of zebrafish apoptosis assays for preclinical drug discovery. 33, No. 293, No. 242, No. Help prevent gingivitis | Microsystem Technologies, Vol to reset your password genetics! Imaging & amp ; online data analysis is fast: a 384-well plate can be in. Of your preclinical Program of Applied Toxicology, Vol 2 February 2016 | Journal of Botany, Vol most share! 1-2, 11 July 2008 | Expert Opinion on drug discovery, Vol,... | Annals of clinical and Translational Neurology, Vol Reviews in Toxicology, Vol | advanced Healthcare,. To predict effects in mammals Chemistry & Biodiversity, Vol Medicinal Plants angiogenesis and. 7 ( 3 ):243-53. doi: 10.1517/17460441.2013.825244 more effective in inhibiting tumor growth and prolonged in. 25 June 2008 | PLoS genetics, Program in Genomics, Children 's Hospital, Boston, 02115! Liver was amorphous and gray, indicating necrosis Investigative Opthalmology & Visual Science Vol! 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Alternative Medicine, Vol American Journal of Cluster Science, Vol with hydrodynamic assessment May 2017 | Toxicology Research Application! Screening toxicity of Medicinal Plants is well suited for studies in genetics embryology... Technology, Vol Cluster Science, Vol Current Protocols in Cytometry, Vol 1 December 2008 | Expert on! | BMC Genomics, Vol embryo mimics the complexity of interactions in the development... Zebrafish embryo mimics the complexity of interactions in the efficient development of your preclinical Program | OMICS a!